Business Wire
09 Jul 2026, 06:00 UTC · 4h ago
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The Phase 3 CARDIO-TTRansform trial for eplontersen in patients with ATTR-CM failed to meet its primary efficacy endpoint of cardiovascular mortality and recurrent CV clinical events. — Failure of a primary endpoint in a Phase 3 trial significantly reduces the likelihood of regulatory approval and future revenue streams for the drug candidate.
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The Phase 3 trial for eplontersen failed to meet its primary efficacy endpoint.
As a partner in the trial, the failure of the primary efficacy endpoint is a negative development.
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[mutual] Ionis Pharmaceuticals and AstraZeneca are partners in the Phase 3 trial for eplontersen.
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