Proactive Investors
09 Jul 2026, 07:50 UTC · 1h ago
AstraZeneca's £19bn blow as Wainua heart drug fails key late-stage trial
NewsImpactScreener rates every claim in this story for market impact and maps it to the tickers most exposed.
Proactive Investors
09 Jul 2026, 07:50 UTC · 1h ago
NewsImpactScreener rates every claim in this story for market impact and maps it to the tickers most exposed.
What the story claims
4 claims · each scored for market impact
AstraZeneca's Wainua drug failed its Phase III CARDIO-TTRansform trial for heart disease, missing its primary endpoint of reducing cardiovascular deaths and recurrent events. — The failure of a high-profile Phase III trial removes a major potential revenue stream and led to an immediate 9.55% drop in share price.
-0.80The trial failure may lead investors to reassess the risk and probability of success for two other upcoming Phase III readouts: SERENA-4 (breast cancer) and AVANZAR (lung cancer). — Negative trial results often create a 'read-across' effect where the market lowers confidence in a company's broader R&D pipeline.
-0.40Citi had modeled peak sales for Wainua in ATTR-CM at approximately $6.2 billion. — This quantifies the significant loss of projected future cash flow resulting from the trial failure.
-0.30Continue reading
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Wainua remains approved in over 20 countries for the polyneuropathy of hereditary transthyretin-mediated amyloidosis, an indication unaffected by the trial failure. — This provides a slight floor to the negative news by confirming that existing revenue from other indications is preserved.
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